I will be doing an FET in March/April, I started taking 4mg of estrace on cd 21. I credit the advice I received on this forum both from members and from experts, my infertility doctor and my push for the estrogen priming protocol for the family that I have today. 1997-2023 BabyCenter, LLC, a Ziff Davis company. Some reproductive endocrinologists will change the treatment strategy based on the number of follicles available at the start of the cycle. My clinic doesn't like it. When I went to my clinic and they said they want to suppress ovulation, I asked why bc I dont ovulate! IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). I only felt icky on the ganirelix. I dont know as much about micro flare. Estrogen Priming Protocol- EPP Experiences. Confirms hormone levels are baseline and gets antral follicle count as a basis for cycle prognosis. Candice maybe11 129 Dec 08, 2009 #3 Hi, The results are below and as you can see, success rates do seem to drop off after 300 IUs per day of gonadotropin. This is standard practice when ordering from Ukraine, according to customers wh. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I started taking 4mg of estrace on cd 21. Our usual regimen is similar to those proposed below: hysteroscopy, prolonged estrogen priming, Estring for local effects, baby aspirin, vaginal phosphodiesterease inhibitors, pentoxifylline, acupuncture, etc., with admittedly little data to support any of our treatment strategies. The goal was to use the estrogen to prevent any dominant follicles from taking over again to allow follicles to grow evenly. I'm 35 and going through my first IVF cycle. During cycle 1 you use OPKs to track your LH surge and ovulation. Create an account or log in to participate. Most experts believe these women just dont seem to respond to increased doses and so above a pretty low threshold of gonadotropin, success rates dont seem to budge much. (51.2% vs 25%; p = 0.047) were noted. Infertility Support Community in Partnership with RESOLVE. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). I am also preparing to do estrogen priming again. to keep trying as well as using our FSA max 3 years in a row. Was wondering since your AMH was good and FSH, why did they recommend the Estrogen priming protocol for you? I also did estrogen priming with the mini. Estrogen priming is pretty standard for over 40. Are you sure you want to block this member? FertilitySmarts Inc. - I am, Hi Ladies! Inhibin is an often overlooked hormone which suppresses (or inhibitits) the release of FSH from your brain during the last week of the cycle (FSH is the chief hormone responsible for making your eggs "grow"). We have been TTC 14 months, but diagnosed at 6 months so did injectables and TI for 3 cycles without bp, although my follicles responded well. The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. It's an estrogen priming protocol. E2 level 96.4. Hi there. | Contributor. (Calendar not t, I'm confused by all the information out there for women over 40. ER sept 29th - 11 follicles, 9 eggs retrieved Thanks for sharing your story. Our first cycles sound pretty similar. I hope a tweak of the protocol will help or maybe it was just an off cycle for me. By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. Hottest Topics -- Last 30 Days Just devastated with my results today so just want to cry it out and then I will respond to you. I did that back in the beginning of the year but I ovulated in my own and terrified it might happen again. Estrogen priming through luteal phase and stimulation phase improved ovarian responsiveness and this may lead to an increase in pregnancy rate in poor responders with failed cycle. February 7 - lost our little twin, Baby B had no heartbeat at 20 weeks, June 8, 2011 - DD was born healthy and her twin brother was born to Heaven. Anyhoo, I am just curious whose done this and what the difference was in terms of their egg numbers and quality.especially if anyone used it for quality. Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. The first question is naturally, which protocol is more likely to deliver a baby, and when investigators looked at the two most popular strategies, Long Agonist and Antagonist, it became clear both were equally effective in the general IVF population. I have AMH of 0.1 or something like that. Fortunately, there are a few steps you can take to prevent and. Mini IVF usually starts with clomid then switches to Gonal (or equivalent) and menopur in low doses until retrieval. This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. It will workjust have faith! Second, this study was only done in cycles using a fresh transfer. I'll keep my fingers crossed for you as I see you just did an IUI. I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. Hi there. Thanks! Are they all the same thing? As we show in the example below, during every step of IVF a certain number of eggs or embryos are lost, especially in the middle part of the funnel (growing embryos that are chromosomally normal). Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. Within both, doctors can prescribe as much gonadotropin as theyd like. Anyways, just wanted to mention that in case you want to ask your RE about it. Best of luck. IVF#1 with ICSI spring 2006 - 3 eggs retrieved, one transferred - BFN This comes from a 38,000 patient European registry. Ivf doctor recommendation in nyc or bklyn, Low Ovarian Reserve and Poor Responder to IVF, Ladies 45 and older TTC - *infertility due to age only*. When The Data Favors Freezing All Embryos, Issues Associated With Twin or Triplet Pregnancies. In some cases, priming may not be required. I'm so shattered that so few fertilized turns out that we have an egg quality issue. I had success with EPP after failing with other protocols. I am about to start my 4th IVF cycle. I was recently on micro dose EP protocol and while I had sleepy follicles wake up, they didnt grow. Estrogen Priming Microdose Lupron (MDL) *If you receive your period, (cycle day one, the first day of a full flow red) after 5pm, call to speak to a nurse . You still may have a BFP, so let's wait to see before we say it didn't work!! There are 2 - 3 core protocols: the Long Agonist, Antagonist and Flare. Yes, I did antagonist for IVF 1, 2 and 3. We use cookies to improve your experience on this website and so that ads you see online can be tailored to your online browsing interests. Dwarf Mr Snow, Fred's Tie Dye, Saucy Mary, Sweet Scarlet, Kangaroo Paw Green, Idaho Gem and Banana Toes are just a few of the varieties one gardener is growing in a 4x8 bed of "bulletproof" tomatoes. They said they would put me in the 21 day long protocol. What affect did the epp have on your follicles? Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. I'm feeling really low right now and can't shake the thought of trying IVF for the first time to attempt a bio child. that cycled failed. Patients using EPP exhibited similar clinical PRs (21.5% vs. 21.4%) and live birth rates (15.0% vs. 15.3%) per started cycle. Some people prefer the term Diminished Ovarian Reserve or Low Egg Reserve for patients who meet this criteria, as the ovarian response to medications for this group is not always necessarily poor, but rather is simply expected to be lower at their given baseline. To bridge that gap, doctors prescribe drugs that woman take at the start of a cycle to instigate growth of ovarian follicles that contain eggs. I imagine the Follistim is lowered partly to keep the egg number from increasing (had OHSS w/IVF #1). Weill Cornell Medical Center, Division Chief There are a number of drugs that can be tacked onto the beginning of a cycle that may increase the odds of success. maternal age" i.e. :) Keep us posted on your progress! This is caused by insufficient potassium reaching the fruit due to environmental factors such as high air/soil temperatures and overcast skies or heavy fruit load on plants with lower organic matter content in their soils. The misoprostol was not expensive; on average, it's about $30. Search While gonadotropin is the critical drug in most every protocol, its not the only drug. What To Do When PGT-A & Grading Results Conflict? TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. A third option, the Flare protocol is used less often and only in very specific patient types (often poor responders). It helps your lining and encourages your eggs to all grow at the same rate. 05/18/2018 23:18 Subject : Protocol . First, the analysis was retrospective and not prospective. The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. my RE is going back to the drawing board for my final IVF. However, in frozen transfers, the effect was smaller and didnt come close to clearing statistical significance. For free! Most of the encouraging studies have been in poor responders, but because the trials were so small, most never met statistical significance. I think you both are at Cornell (were) with this estrogen priming protocol will you try again with them, and request not to do estrogen priming? IVF#3 September 2009 - cancelled - poor response Changed MD's and now this is the protocol they have in place for me. Worked for me! Good luck! EPP is an aggressive form of an IVF Antagonist Protocol. As you can see below, success rates dropped. I'm 40, doing IVFdue to age and a mc at 10 weeks due to Trisomy18. However, when it comes to specific IVF populations, its clear that certain strategies and doses are better than others. I just had my first IVF and it was unsuccesful. Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. 45 and over - who are trying to get pregnant. Several functions may not work. 2nd IVF/ICSI age 42 : Menopur 425; 2 eggs; 2 fertislised; transfer day 5; BFN I understand the idea for the patch is to help time the growth of follicles vs. increase the number? Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. The answer lies in the drug the protocol uses to trigger the eggs to mature so that they can be retrieved. Fx! I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. This is the oldest IVF protocol and is especially effective in preventing premature ovulation during the cycle. I did EPP with my 3rd cycle and it didn't help. Avery & Sydney born June 12/11 at 30w1d. This drug works indirectly by prompting the brain to produce more gonadotropin to signal the ovaries to grow follicles -- so it's not directly stimulating the ovary. High FSH. IVF #5 was EPP and HGH. IVF#5 July 2010 - will be using estrogen priming He did say there are some studies that DHEA and CoQ10 could help, but the, Hi all. I was on the highest dosage of Gonal with that cycle. You should also label each packet with the variety name, date, and a brief description (e.g. Today, most IVF cycles use a frozen transfer whereby embryos are frozen and transferred at least a month after the retrieval. Around 50-60% of couples find success with IUI after 5 cycles, which is about a 10-20% success rate per cycle. The hypothesis is that if we treat patients prior to starting their IVF cycle with estrogens ( the estrogen priming protocol) or androgens ( such as DHEA) , they will produce more eggs because more follicles will be recruited when we start the superovulation . . To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). Estrogen Priming Protocol: For some women, especially for those who have diminished ovarian reserve, it becomes necessary to help the response to the Antagonist protocol. From NE Ohio to North Central Mississippi, everyone has their own ideas and preferences for what they will plant this year. This hormone is injected by the patient and directly instigates the ovaries to grow more follicles. My doc started me on estrogen patch, one patch changing every 3 days until my period for 5 days and I just took it off and will be takingClomiphene after a day of taking off the patch, then after a day start stim. But I will be asking the best hardcore questions I can come up with about EPP. Thank you for subscribing to our newsletter! Was one of my worst cycles. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN 6 responded, 5 retrieved, 3 fertilized normally, put all 3 back in at 3dpt - I am currently 27 weeks with one baby girl. 10 retrieved, 6 mature, 6 fertilized (half with ICSI), transferred two 8-cell embryos on day three (both with moderate fragmentation, graded B and C-), the four remaining arrested by day 5. I did estrogen and testosterone priming on my second ivf because I was oversuppressed during my first cycle. I did a phone consult with Sher and he suggested the conversion protocol to me as well. Froze 3. ET oct 2nd - 2 embryos transferred Our last cycle was such a bust! So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). I will have retrieval hopefully this weekend and will let you know what happens. Still seems to have had plenty of effect though. I had success on an EPP. IVF#2 started sept 19th 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. :-/. Find other members in this community to connect with. So, I'm 39 with Amh of 0.07 (undetectable) and FSH of 9. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. i had success with DE. I also did ganirelix during this time. I have been diagnosed with low ovarian reserve. We are OOP as well. All rights reserved. My second included BCP before stimulating and I didnt stimulate well. Starting CD21, I was applying Vivelle patch every other day until my cycle started. - 1st follicle check u/s and b/w. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. So there's one med w apositive side effect! Several functions may not work. They said that they look at FSH less now as they find it too unreliable. I was 41 at SG and they also put me on BCPs and i knew it was going to oversupress me -- and it did. Sign up now for your monthly dose of fertility info, experiences, and insight. Transfer was canceled. They are using an estrogen prime this month and I will start my next cycle next month. Very helpful! Looking for info/success stories with Estrogen priming protocol with DOR. Looking for info/success stories with Estrogen priming protocol with DOR. We ended up refinancing our home and getting help from family. It seems less is more in my case!! New doctor recommended EPP to promote more even follicle growth. My body seemed to appreciate the extra estrogen. Had two follicles but one disappeared day of egg retrieval. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. I was not informed of this ahead of timeand was pretty upset that that they threw away something that might have had a chance. They monitor the follicle size and u do the trigger still so the know when to retrieve. Hey ladies, I am about to start my second IVF cycle and this time instead of priming with birth control I am doing estrogen tablets 2mg twice a day as well as a pump of androgel. How it works: It's a two cycle process. Good luck! I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. He also said he would start with BCPs to suppress ovulation- he explained why, but at my age that just doesn't sound like a good idea to be suppressing anything. Heres an example from the same study. Any info welcomed!! Join Tomato Lovers & Participate in the Ukrainian Tribute Growout! As a result, its hard to correct for confounders like the fact that harder cases may (or in our minds, probably) had been given more drug and so the underlying condition, rather than the dose taken, contributed to the lower rates of success. When do you start your next cycle? Trying concieve since 40 Our mission is to be a trusted partner in helping you understand your reproductive health and to support and empower the choices you make along the way.

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